牛雪梅的简历

Laboratory for Conservation and Utilization of Bio-resources

Yunnan University

Kunming 650091

Yunnan, China

教育和工作经历

1989年9月-1993年7月, 广西师范大学化学系, 获理学学士

1993年9月-1996年7月, 广西师范大学化学系, 获理学硕士, 有机化学(药物合成)

1996年8月-1999年2月, 广西师范大学化学化工系, 讲师, 有机化学

1999年3月-2001年12月, 中国科学院昆明植物研究所, 获理学博士, 植物化学

2002年1月-2003年6月, 中国科学院昆明植物研究所, 助理研究员, 植物化学, 天然产物化学

2003年7月-2004年2月, 中国科学院昆明植物研究所, 副研究员, 植物化学, 天然产物化学

2004年3月- 2004年9月, 香港中文大学中医学院, 博士后, 高等真菌的次生代谢产物

2004年10月-2006年3月, 德国莱布尼兹天然产物及感染生物学研究所生物有机化学系, DAAD-Leibniz博士后, 微生物次生代谢产物

2006年4月-2007年7月, 德国马普化学生态研究所生物化学系, 博士后, 化学生态学

2007年11月--, 云南大学生物资源保护与利用重点实验室, 研究员, 次生代谢产物及功能

EDUCATION AND EXPERIENCE:

09/1989-07/1996, Studies of Chemistry at Department of Chemistry, Guangxi Normal University, China:

Master’s thesis on 'synthesis of allantoin’

07/1996-03/1999, Lecturer at Department of Chemistry, Guangxi Normal University, Guilin, China

03/1999-12/2001, PhD thesis at State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, The Chinese Academy of Sciences

01/2002-06/2003, Assistant Professor at State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, The Chinese Academy of Sciences

07/2003-12/2007, Associate Professor at State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, The Chinese Academy of Sciences

03/2004-09/2004, Postdoctoral Fellow at School of Chinese Medicine, The Chinese University of Hongkong,

10/2004-03/2006, Postdoctoral Fellow at Leibniz Institute for Natural Product Research and Infection Biology Hans-Kn?ll-Institute (HKI),Jena, Germany

04/2006-07/2007, Postdoctoral Fellow at Department of Biochemistry, & Research Group Biosynthesis/NMR, Max Planck for Chemical Ecology, Jena, Germany

11/2007-present, Professor at Laboratory for Conservation and Utilization of Bio-resources, Yunnan University, Kunming, China

AWARD：

2004.10-2006.3, Postdocoral fellowship by German Academic Exchange Service (Deutscher Akademischer Austauschdienst, DAAD)-Leibniz

主要研究方向：

微生物和植物中的天然产物的分离和结构鉴定

捕食线虫真菌的化学防御机制

应用酶和微生物的生物转化

植物与相关微生物之间的化学相互作用

RESEARCH INTERESTS：

Isolation and structure elucidation of natural products from microorganisms and plants in Yunnan

Use of enzymes and microorganisms for biotransformations

Chemical defense mechanism of nematode-trapping fungi

Chemical interaction between plants and the associated microorganisms

承担的主要科研项目：

目前承担或参与国家自然科学基金委、云南省科技厅等在研项目。

PUBLICATIONS (2002-):

1. Wu DK, Zhang CP, Zhu CY, Wang YL, Guo LL, Zhang KQ, and Niu XM*. Metabolites from Carnivorous Fungus Arthrobotrys entomopaga and Their Functional Roles in Fungal Predatory Ability,J. Agric. Food Chem.2013, 61, 4108?4113. (*corresponding author)

2. Luo SH, Hua J, Niu XM, Liu Y, Li CH, Zhou YY, Jing SX, Zhao X, Li SH, Defense sesterterpenoid lactones from Leucosceptrum canum, Phytochemistry, 2013, 86, 29 - 35.

3. Tan JL, Niu XM, Yang GY, Wang L, Duan YX, Han Y, Zhang KQ, Zhang CM. Quantitative Determination of Phytosterols in Tobacco Leaves by UPLC-MS/MS. J Liq Chromatogr R T, 2013, 36, 591-599.

4. Guo JP, Zhu CY, Zhang CP, Chu YS, Wang YL, Zhang JX, Wu DK, Zhang KQ, NiuXM*. Thermolides, Potent Nematocidal PKS-NRPS Hybrid Metabolites from Thermophilic Fungus Talaromyces thermophilus, J Am Chem Soc, 2012, 134(50), 20306-20309. (*corresponding author)

5. Zhang HX, Tan JL, Wei LX, Wang YL, Zhan CP, Wu DK, Zhu CY, Zhang Y, Zhang KQ, Niu XM*. Morphology Regulatory Metabolites from Arthrobotrys oligospora. J Nat Prod, 2012, 75(7), 1419-1423. (*corresponding author)

6. Wu HY, Wang YL, Tan JL, Zhu CY, Li DX, Huang R, Zhang KQ, Niu XM *. Regulation of the Growth of Cotton Bollworms by Metabolites from an Entomopathogenic Fungus Paecilomyces cateniobliquus. J Agric Food Chem,2012, 60(22), 5604-5608. (*corresponding author)

7. Luo SH, Liu Y, Hua J, Niu XM, Jing SX, Zhao X, Schneider B, Gershenzon J, Li SH, Unique Proline-Benzoquinone Pigment from the Colored Nectar of Bird's Coca Cola Tree Functions in Bird Attractions. Organic Lett,2012, 14(16), 4146-4149.

8. Li SH, Nagy NE, Hammerbacher A, Krokene P, Niu XM, Gershenzon J, Schneider B. Localization of Phenolics in Phloem Parenchyma Cells of Norway Spruce (Picea abies), ChemBioChem, 2012, 13, 2707 - 2713.

9. Guo JP, Tan JL, Wang YL, Wu HY, Zhang CP,Niu XM*, Pan WZ, Huang XW, Zhang KQ. Isolation of Talathermophilins from a Thermophilic Fungus Talaromyces thermophilus YM3-4. J Nat Prod, 2011, 74(10), 2278-2281. (*corresponding author)

10. Wei LX, Zhang HX, Tan JL, Chu YS, Li N, Xue HX, Wang YL, Niu XM *, Zhang Y, Zhang KQ. Arthrobotrisins A-C, Oligosporons from the Nematode-Trapping Fungus Arthrobotrys oligospora. J Nat Prod, 2011, 74(6), 1526-1530. (*corresponding author)

11. Niu XM, Zhang KQ. Arthrobotrys oligospora: a Model Organism for Understanding the Interaction between Fungi and Nematodes. Mycology, 2011, 2(2), 59-78.

12. Niu QH, Tian YX, Zhang L, Xu XE, Niu XM, Zhang KQ, Huang XW. Overexpression of the Key Virulence Proteases Bace16 and Bae16 in Bacillus nematocida B16 to Improve its Nematocidal Activity.J Mol Microb Biotech, 2011, 21, 130-137.

13. Yang JK, Wang L, Ji XL, Feng Y, Li XM, Zou CG, Xu JP, Ren Y, Mi QL, Wu JL, Liu SQ, Liu Y, Huang XW, Wang HY, Niu XM, Li J, Liang LM, Luo YL, Ji KF, Zhou W, Yu ZF, Li GH, Liu YJ, Li L, Qiao M, Feng L, Zhang KQ. Genomic and Proteomic Analyses of the FungusArthrobotrys oligospora Provide Insights into Nematode-Trap Formation. Plos Pathog, 2011, 7, e1002179.

14. Yang JK, Zhao XN, Liang LM, Xia ZY, Lei LP, Niu XM, Zou CG, Zhang KQ. Overexpression of a Cuticle-Degrading Protease Ver112 Increases the Nematicidal Activity of Paecilomyces lilacinus. Appl Microbiol Biot, 2011, 89, 1895-1903.

15. Li GH, Yang ZS, Zhao PJ, Zheng X, Luo SL, Sun R, Niu XM, Zhang KQ. Three New Acorane Sesquiterpenes from Trichoderma sp. YMF1.02647. Phytochemistry Lett, 2011, 4, 86-88.

16. Chu YS, Niu XM *, Wang YL, Guo JP, Pan WZ, Huang XW, Zhang KQ. Isolation of Putative Biosynthetic Intermediates of Prenylated Indole Alkaloids from a Thermophilic Fungus Talaromyces thermophilus. Organic Lett, 2010, 12(19), 4356-4359. (*corresponding author)

17. Niu XM, Wang YL, Chu YS, Xue HX, Li N, Wei LX, Mo MH, Zhang KQ. Nematodetoxic Aurovertin-Type Metabolites from a Root-Knot Nematode Parasitic Fungus Pochonia chlamydosporia. J Agric Food Chem,2010,58(2), 828-834.

18. Li CH, Niu XM, Luo Q, Xie MJ, Luo SH, Zhou YY, SH Li. Novel Polyesterified 3,4-seco-Grayanane Diterpenoids as Antifeedants from Pieris formosa.Organic Lett, 2010, 12 (10), 2426-2429.

19. Luo SH, Luo Q, Niu XM, Xie MJ, Zhao X, Schneider B, Gershenzon J, Li SH. Glandular Trichomes of Leucosceptrum canum Harbor Defensive Sesterterpenoids. Angew Chem Int Edit, 2010, 49, 4471-4475.

20. Niu QH, Huang XW, Zhang L, Xu JP, Yang DM, Wei KB, Niu XM, An ZQ, Bennett JW, Zou CG, Yang JK, Zhang KQ. A Trojan Horse Mechanism of Bacterial Pathogenesis against Nematodes. Proc Natl Acad SciUSA, 2010, 107 (38), 16631-16636.

21. Yang ZS, Li GH, Zhao PJ, Zheng X, Luo SL, Li L, Niu XM, Zhang KQ. Nematicidal activity of Trichoderma spp. and Isolation of an Active compound. World J Microb Biot. 2010, 26, 2297-2302.

22. Mi QL, Yang JK, Ye FP, Gan ZW, Wu CW, Niu XM, Zou CG, Zhang KQ. Cloning and Over expression of Pochonia chlamydosporia Chitinase Gene Pcchi44, a Potential Virulence Factor in Infection against Nematodes. Process Biochem,2010, 45(5), 810-814.

23. Zhao X, Zheng GW, Niu XM, Li WQ, Wang FS, Li SH, Terpenes from Eupatorium adenophorum and their Allelopathic Effects on Arabidopsis Seeds Germination.JAgric Food Chem, 2009, 57, 478-482.

24. Niu XM, Dahse HM, Menzel KD, Lozach O, Walther G, Meijer L, Grabley S, Sattler I. Butyrolactone I Derivatives from Aspergillus terreus Carrying an Unusual Sulfate Moiety, J Nat Prod, 2008,71, 689-692.

25. Huang XS, He J, Niu XM, Menzel KD, Dahse HM, Grabley S, Fiedler HP, Sattler I, Hertweck C. Benzopyrenomycin, a Cytotoxic Bacterial Polyketide Metabolite with a Benzo[a]pyrene-Type Carbocyclic Ring System. Angew Chem Int Edit, 2008, 47, 1-5.

26. Li SH, Niu XM, Zahn S, Gershenzon J, Weston J, Schneider B. Diastereomeric Stilbene Glucoside Dimers from the Bark of Norway Spruce (Picea abies). Phytochemistry, 2008, 69, 772-782.

27. Niu XM, Li SH, G?rls H, Schollmeyer D, Hilliger M, Grabley S, Sattler I. Abyssomicin E, a Highly Functionalized Polycyclic Metabolite from Streptomyces species. Organic Lett, 2007, 9(13), 2437-2440.

28. Niu XM, Li SH, Sun HD, Che CT. Two new Lanostanoids from Ganoderma resinaceum.J Asian Nat Prod Res, 2007, 9(7), 659-664.

29. Zhao Y, Niu XM, Qian LP, Liu ZY, Zhao QS, Sun HD. Synthesis and Cytotoxicity of Some New Eriocalyxin B Derivatives. Euro J Med Chem, 2007, 42(4), 494-502.

30. Niu XM, Li SH, Sun HD, Che CT. Prenylated Phenolics from Ganoderma fornicatum. J Nat Prod, 2006, 69(9), 1364-1365.

1、包装上

外层是金色包装，里面还有一层，同样是金色的纸盒。侧面有防伪标，钢笔，合格证，保修卡都有

2、外观上

这支钢杆的派克威雅，整体的感觉，做工就一下子好多了，包括笔杆笔帽的接缝严丝合缝，黑色的一头一尾的配色也比较舒服。打开笔帽，能看到，笔尖，笔握都是一样的， 两支钢笔的笔握都是金属。

3、书写体验

感觉派克威雅的笔尖既不像欧美钢笔，类似lamy Safari，也不像日系钢笔，比如今天这两支派克威雅都是F尖，但是写出来的字，其实不像Lamy F那么粗，也不像日系钢笔的F那么细，属于中间位置。

整个书写感受呢，笔尖处理的既不像safari那么圆润顿挫，也不像日系钢笔那种楔形，但是又能让你感觉到一些角度变化。

4、笔尖

看下笔尖，很简单，除了派克的logo，任何花纹都没有，并且笔尖显得很短小，这个也是我当年不太喜欢这款钢笔的原因之一。除了包尖，不太喜欢这种短小的笔尖。貌似犀飞利的笔尖也显得比较短小。

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